Are Dean and Cain related?

Cain and Abel (both deceased) – It was revealed by the Archangel Michael that through the Winchester bloodline, Dean, Sam, Adam, Henry, and John are descendants of Cain and Abel, making John a vessel and Dean his true vessel.

What did John whisper to Dean?

Before dying, John tells Dean, if he can’t save Sam, he’ll have to kill him, should he become evil.

Are Dean and Castiel related?

Since his introduction in the season-four opener “Lazarus Rising,” fans of the show have vocally shipped Castiel with older brother Dean — and the show’s cast and crew have long since taken to acknowledging and playing around with that fact.