Can you pass on polycystic kidney disease?

Can you pass on polycystic kidney disease?

Autosomal dominant polycystic kidney disease (ADPKD). Only one parent needs to have the disease for it to pass to the children. If one parent has ADPKD , each child has a 50% chance of getting the disease. This form accounts for most of the cases of polycystic kidney disease.

What causes polycystic kidney disease?

Mutations in the PKD1, PKD2, and PKHD1 genes cause polycystic kidney disease. Mutations in either the PKD1 or PKD2 gene can cause autosomal dominant polycystic kidney disease; PKD1 gene mutations cause ADPKD type 1, and PKD2 gene mutations cause ADPKD type 2.

Can polycystic kidney disease skip a generation?

A parent with autosomal dominant PKD has a 50 per cent chance of passing the altered gene (PKD1 or PKD2) and associated condition to each of their children. If a person doesn’t inherit the gene, there is no chance of their children inheriting the gene because it never ‘skips’ a generation.